応用酵素学研究室
Lab. of Applied Enzymology
(旧・生体高分子学)
Welcome to the Lab. of
Applied Enzymology
Enzymes are involved in a wide range of reactions in living organisms, from energy metabolism to the synthesis of biological substances such as lipids and hormones, as well as the replication and expression of genes.
The Lab. of Applied Enzymology focuses on elucidating enzyme functions at the molecular level from the perspectives of physical chemistry, organic chemistry and structural biology. The laboratory also works on the application of enzymes to analysis and the production of useful substances.
We currently focus on..
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Enzymes involved in the biosynthesis and metabolism of isoprenoid compounds, especially membrane lipids, in Archaea (read more)
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Enzymes and proteins that are involved in the synthesis and regulation of vitamins B6 and B9 and in the metabolism of amino acids. (read more)
NEWS
2024. 6. 1 | Website renewal!
2024. 4. 1 | New members have joined.
Recent Papers
Kanno K, Kuriki R, et al. Archaeal mevalonate pathway in the uncultured bacterium Candidatus Promineifilum breve belonging to the phylum Chloroflexota. Appl Environ Microbiol. 2024 in press
Matsuo H, Yamada N, Hemmi H, Ito T. Identification of YigL as a PLP/PNP phosphatase in Escherichia coli. Appl Environ Microbiol. 2024 in press
Yoshida R, Motoyama K, Ito T, Hemmi H. Effects of producing high levels of hyperthermophile-specific C25,C25-archaeal membrane lipids in Escherichia coli. Biochem Biophys Res Commun. 2024 Jul 4;729:150349.
Komeyama M, Kanno K, Mino H, et al. A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway. Front Microbiol. 2023;14:1150353.
Ito T, Muto N, Sakagami H, Tanaka M, Hemmi H, Yoshimura T. D-amino acid auxotrophic Escherichia coli strain for in vivo functional cloning of novel D-amino acid synthetic enzyme. FEBS J. 2023;290(11):2895-2908.
Aoki M, Vinokur J, Motoyama K, et al. Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways. J Biol Chem. 2022;298(7):102111.